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POTS, MCAS & ALPIMS: A Nervous–Immune Regulation Guide

Conditions like Postural Orthostatic Tachycardia Syndrome (POTS) and Mast Cell Activation Syndrome (MCAS)often co-occur with ALPIMS traits, creating overlapping storms of dysregulation. These are not “rare flukes”—they are clues that the nervous and immune systems are overreactive and under-supported.

🧭 Regulation is possible when the body feels safe enough to shift out of survival mode.


🧩 How POTS and MCAS Relate to ALPIMS

SystemPOTS/MCAS FeatureALPIMS Domain Link
AutonomicHeart rate spikes, dizziness, fatigueLaxity, Anxiety
VascularFlushing, blood pooling, lightheadednessPain, Sensory
ImmuneHistamine surges, rashes, GI symptomsImmune, Sensory
EndocrineCrashes after exertion, temperature swingsMood, Pain
NeurologicalBrain fog, overstimulation, panicAnxiety, Sensory, Mood

These conditions reflect impaired homeostasis and “stuck” Cell Danger Response (CDR) states. Stabilizing one domain helps others regulate too.


🔧 Regulation Strategies by System

🧠 Nervous System (POTS, Overwhelm, Sensory Dysregulation)

  • Daily vagal toning: gentle hums, long exhales, cold water splash
  • Positional pacing: recline > stand, avoid fast transitions
  • Sensory scaffolding: low light, noise buffers, structured transitions
  • Slow nervous input: weighted blankets, pressure garments, grounding touch

🦠 Immune System (MCAS, Food Sensitivity, Flare Triggers)

  • Low-histamine, low-additive diet
  • Supplements with care: quercetin, vitamin C, DAO (medical advice required)
  • Filter your environment: air purifiers, non-toxic cleaners, avoid strong scents
  • Titrate exposures: sunlight, new foods, smells—start small, observe zone

💓 Cross-System Regulation

  • Zone tracking: log symptoms, triggers, and recoveries in ALPIMS format
  • Compression wear: socks, garments to support circulation and proprioception
  • Salt + hydration protocols: if tolerated, balance fluid/sodium intake
  • Movement as medicine: stretching, recumbent motion, somatic resets

🧾 Helpful Templates & Downloads

🔹 POTS + MCAS Zone Tracker
🔹 Trigger–Response–Recovery Log
🔹 Symptom Interaction Wheel: ALPIMS + Dysautonomia
🔹 Nervous–Immune Daily Care Planner

🔗 [Download: Full Nervous–Immune Regulation Toolkit]
🔗 [Explore: Low-Stim Meal Plans, Emergency Flare Cards, and Soothing Routines]


🌿 You’re not too sensitive. You’re exquisitely attuned to a body asking for safety.

With consistency, compassion, and custom pacing, the system can rebuild tolerance.

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