Supplements

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⚠️ Supplement Guide Disclaimer

This supplement guide is for informational and educational purposes only. It is not intended as medical advice and should not be used to diagnose, treat, cure, or prevent any health condition. The supplements listed may support symptoms associated with ALPIMS-related conditions (Anxiety, Laxity, Pain, Immune, Mood, Sensory), but individual responses vary.

Please consult with a qualified healthcare provider—preferably one who is familiar with MCAS, neurodivergence, POTS, and multisystem sensitivities—before starting, changing, or discontinuing any supplement.

Many people with ALPIMS-related conditions are sensitive to ingredients, dosages, and excipients. It is essential to:

Start with low doses
Introduce one new supplement at a time
Use MCAS-safe or clean-label brands
Monitor for adverse reactions

This guide does not replace the need for individualized medical care. Always seek professional guidance for your unique situation.

🧠 Magnesium Glycinate

Primary benefit: Calms anxiety, reduces pain, supports sensory regulation and sleep
Salicylate: Well-tolerated
Dose: 100–400 mg
Brands: Pure Encapsulations, Seeking Health
Cautions: May lower blood pressure (POTS); start low with MCAS; avoid if diarrhoea-prone
Benefit priority: High – essential for anxiety and muscle regulation
Best zone to take in: 🟢 Green / 🟡 Yellow

🌿 L-theanine

Primary benefit: Promotes calm focus, reduces anxiety and sensory overload, supports sleep
Salicylate: Low
Dose: 100–200 mg
Brands: Thorne, Jarrow Formulas
Cautions: Generally safe; avoid combining with sedatives; rare overstimulation possible
Benefit priority: Medium – helpful for sensory modulation
Best zone to take in: 🟢 Green / 🟡 Yellow

😴 GABA (PharmaGABA)

Primary benefit: Promotes nervous system calm, supports sleep, sensory regulation
Salicylate: Low
Dose: 100–250 mg
Brands: Natural Factors, Thorne
Cautions: May not be effective for everyone; use PharmaGABA over synthetic; avoid in severe MCAS
Benefit priority: Medium – gentle calming support
Best zone to take in: 🟡 Yellow / 🔴 Red

🍊 Vitamin C (Buffered, Non-Citrus)

Primary benefit: Supports immune health, collagen formation, antioxidant defense
Salicylate: Avoid citrus-based forms
Dose: 250–1000 mg
Brands: Klaire Labs Buffered C, Nutribiotic
Cautions: High doses may trigger histamine; avoid chewables/flavored versions
Benefit priority: Medium – structural and immune support
Best zone to take in: 🟢 Green

💅 Silicon / Silica (Orthosilicic Acid)

Primary benefit: Supports collagen, skin, and connective tissue
Salicylate: Low
Dose: 5–10 mg
Brands: Hubner Original Silica, Eidon Ionic Minerals
Cautions: Choose clean brands; generally well tolerated
Benefit priority: Medium – connective tissue maintenance
Best zone to take in: 🟢 Green

🦴 Proline + Lysine

Primary benefit: Amino acids for collagen synthesis and tissue repair
Salicylate: Low
Dose: 500 mg each
Brands: Thorne, Designs for Health
Cautions: Well tolerated; works synergistically with vitamin C
Benefit priority: Medium – foundational joint support
Best zone to take in: 🟢 Green

🔥 Magnesium Malate

Primary benefit: Pain and fibromyalgia relief, energy support
Salicylate: Low
Dose: 125–500 mg
Brands: Source Naturals, Pure Encapsulations
Cautions: May be stimulating in sensitive individuals; avoid in evening if energising
Benefit priority: High – pain modulation and energy
Best zone to take in: 🟢 Green / 🟡 Yellow

⚠️ Boswellia

Primary benefit: Inflammation, joint pain
Salicylate: Often high – use cautiously
Dose: 250–500 mg
Brands: Designs for Health (Inflamma-bLOX)
Cautions: May trigger MCAS or salicylate flares; trial only if other anti-inflammatories fail
Benefit priority: Low – selective use only
Best zone to take in: 🟢 Green (if trialing)

⚡ CoQ10 (Ubiquinol)

Primary benefit: Mitochondrial support, brain fog, energy
Salicylate: Low
Dose: 50–200 mg
Brands: Jarrow QH-Absorb, Pure Encapsulations
Cautions: May be activating; avoid at night; choose MCAS-safe versions
Benefit priority: Medium – energy and cognition
Best zone to take in: 🟢 Green

🛡 Quercetin (Low-histamine form)

Primary benefit: Mast cell stabilization, immune modulation
Salicylate: May be citrus-derived — verify source
Dose: 250–500 mg
Brands: Thorne Quercetin Phytosome, Allergy Research Group
Cautions: Start low; may cause herx-type response; useful in long-term MCAS regulation
Benefit priority: High – MCAS and immune support
Best zone to take in: 🟢 Green / 🟡 Yellow

☀️ Vitamin D3

Primary benefit: Mood regulation, immunity, bone health
Salicylate: Low – check oil base
Dose: 1000–2000 IU
Brands: Thorne, Pure Encapsulations
Cautions: Needs magnesium + K2; check labs for optimal dosing
Benefit priority: Medium – mood/immune foundational
Best zone to take in: 🟢 Green

🧬 Zinc (Picolinate or Citrate)

Primary benefit: Immune defense, histamine regulation, wound healing
Salicylate: Low
Dose: 15–30 mg
Brands: Klaire Labs, Pure Encapsulations
Cautions: Take with food; long-term use may lower copper
Benefit priority: Medium – immune and tissue health
Best zone to take in: 🟢 Green

🐟 Omega-3 (Low Histamine Fish Oil)

Primary benefit: Inflammation control, brain function
Salicylate: Neutral – histamine more relevant
Dose: 500–1000 mg EPA/DHA
Brands: Nordic Naturals ProOmega (liquid or capsule-free)
Cautions: May trigger MCAS in sensitive people; refrigerate; consider algae-based alternative
Benefit priority: Low to Medium – helpful but caution needed
Best zone to take in: 🟢 Green (trial only)

😊 SAMe

Primary benefit: Mood lifting, methylation support, joint health
Salicylate: Low
Dose: 200–400 mg
Brands: Jarrow SAMe 200, Doctor’s Best
Cautions: May overstimulate mood in bipolar/anxious profiles; energizing
Benefit priority: Medium – mood-specific
Best zone to take in: 🟢 Green

🧩 Inositol (Myo-Inositol)

Primary benefit: Anxiety, OCD-type traits, sensory regulation
Salicylate: Low
Dose: 500–2000 mg
Brands: Jarrow, Thorne
Cautions: Well tolerated; may cause mild GI upset in large doses
Benefit priority: Medium – ND-friendly support
Best zone to take in: 🟢 Green / 🟡 Yellow

🧪 NAC (N-Acetylcysteine)

Primary benefit: Detoxification, glutamate regulation, antioxidant
Salicylate: Low
Dose: 300–900 mg
Brands: NOW Foods, Pure Encapsulations
Cautions: May increase sulfur load; trial low and monitor MCAS reactions
Benefit priority: Medium – neuro-immune support
Best zone to take in: 🟢 Green (trial only)

💤 Glycine

Primary benefit: Calming neurotransmitter, sleep onset, sensory soothing
Salicylate: Low
Dose: 1000–3000 mg
Brands: BulkSupplements, Pure Encapsulations
Cautions: May cause vivid dreams; trial at lower dose if prone to nightmares
Benefit priority: High – calming and sensory-friendly
Best zone to take in: 🟡 Yellow / 🔴 Red

Melatonin

Primary benefit:
Supports circadian rhythm regulation, sleep initiation, anxiety reduction, and nighttime calming in sensory-sensitive individuals.
Salicylate:
Low, but check for clean formulations — avoid flavored or dyed chewables and time-release tablets with artificial excipients.
Suggested dose:
0.3–2 mg to start (higher doses like 3–5 mg may be too strong or cause grogginess, vivid dreams, or paradoxical alertness in some individuals)
Example brands:
Pure Encapsulations, Thorne, Seeking Health (sub-lingual or low-dose options)
ALPIMS Cautions:DomainConsiderationAnxiety / MoodCan reduce night-time cortisol spikes and hyperarousal; too high a dose may cause next-day grogginess or vivid dreamsSensory / NeurodivergenceOften helpful for autistic individuals with sleep-onset delay; start low to avoid agitationImmune / MCASGenerally low-reactivity; choose dye-free, alcohol-free forms; some MCAS users prefer sublingual liquid or capsules over tabletsPOTS / LaxityMay assist in stabilizing circadian blood pressure dips; monitor next-day fatiguePain / FatigueImproved sleep onset may reduce next-day pain perception and mental fatigue
Benefit priority:
High – foundational for sleep and nervous system repair
Best zone to take in:
🟡 Yellow (vulnerable, trouble winding down)
🔴 Red (flare state, sleeplessness, anxiety spike)