There is some evidence that people with laxity related conditions like hypermobility spectrum disorder and EDS have increased risk of Mast Cell Activation Syndrome (MCAS) and chronic fatigue. This may co-occur with POTS.
Video Source1
- https://complexneurology.com/services/mast-cell-activation-syndrome-mcas/#:~:text=MCAS%20commonly%20occurs%20in%20people,to%20be%20related%20to%20MCAS. ↩︎